THE SCIENCE

HeadaTerm's References

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Migraine Mechanism

1

Migraine may begin when the nervous system becomes overly sensitive to triggers such as stress, sleep changes, hormones, light, or certain foods.

2

The trigeminal nerve pathway becomes activated and sends pain signals from the forehead, face, and head toward the brain.

3

As these signals intensify, users may experience migraine symptoms such as throbbing head pain, light sensitivity, nausea, and recurring attacks.

Advanced e-TNS Targeted Neuromodulation

e-TNS stands for external Trigeminal Nerve Stimulation, the targeted neuromodulation technology at the core of HeadaTerm 2. Designed as a non-invasive, device-based approach, it delivers gentle electrical impulses through a forehead electrode for drug-free migraine prevention support.

Migraine Neuromodulation Mechanisms

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  • HeadaTerm 2 is placed on the forehead, where the electrode delivers controlled electrical impulses to branches of the trigeminal nerve.
  • These signals travel through the trigeminal pathway, a key nerve pathway involved in migraine pain signaling.
  • By modulating trigeminal nerve activity, HeadaTerm 2 is designed to help reduce the frequency of episodic migraine attacks when used regularly.
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Up to 35% more effective than oral medicine

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Published by Emergency Medicine in the United States

Reference

  • Hokenek N M, Erdogan M O, Hokenek U D, et al. Treatment of migraine attacks by transcutaneous electrical nerve stimulation in emergency department: A randomize controlled trial[J]. The American Journal of Emergency Medicine, 2021, 39: 80-85.
  • Kuruvilla, D.E., Mann, J.I., Tepper, S.J. et al. Phase 3 randomized, double-blind, sham-controlled Trial of e-TNS for the Acute treatment of Migraine (TEAM). Sci Rep 12, 5110 (2022). https://doi.org/10.1038/s41598-022-09071-6.
  • Sluka KA, Walsh D. Transcutaneous electrical nerve stimulation: basic science mechanisms and clinical effectiveness. J Pain. 2003 Apr;4(3):109-21.
  • Shealy CN. Transcutaneous electrical nerve stimulation: the treatment of choice for pain and depression. J Altern Complement Med. 2003 Oct;9(5):619-23.
  • Huang W, Kutner N, Bliwise DL. Autonomic activation in insomnia: the case for acupuncture. J Clin Sleep Med. 2011 Feb 15;7(1):95-102.
  • Kirsch DL, Nichols F. Cranial electrotherapy stimulation for treatment of anxiety, depression, and insomnia. Psychiatr Clin North Am. 2013 Mar;36(1):169-76.
  • Schoenen J, Vandersmissen B, Jeangette S, et al. Migraine prevention with a supraorbital transcutaneous stimulator: a randomized controlled trial. Neurology. 2013 Feb 19;80(8):697-704.